Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas.
Genes Dev
; 22(11): 1445-50, 2008 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-18519637
ABSTRACT
The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cells that would normally express ptf1a and become exocrine cells, express the endocrine marker Isl1, indicating a cell fate switch. Surprisingly, a milder reduction of Ptf1a leads to an even greater increase of ectopic endocrine cells, suggesting that Ptf1a also plays a role in promoting endocrine development. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Ilhotas Pancreáticas
/
Regulação da Expressão Gênica no Desenvolvimento
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Proteínas de Peixe-Zebra
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Pâncreas Exócrino
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article