Cross interaction between auxiliaries: the chirality of amino alcohols by NMR.
Org Lett
; 10(13): 2729-32, 2008 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-18522388
ABSTRACT
The absolute configuration of sec/prim- and prim/sec-1,2-amino alcohols is determined by comparison of the (1)H NMR chemical shifts of the auxiliary OMe or CalphaH groups at the corresponding bis-( R) and bis-( S)-MPA derivatives. This is the first NMR method that allows the assignment of absolute configuration without resorting to the shifts of hydrogens at the substrate and is based on the cross anisotropic interactions between auxiliaries.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
/
Amino Álcoois
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article