Drug delivery in acute myeloid leukemia.
Expert Opin Drug Deliv
; 5(6): 653-63, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18532921
ABSTRACT
BACKGROUND:
Acute myeloid leukemia was among the first malignancies to be cured by drug therapy alone, but overall survival rates remain unsatisfactory and have changed little over the past 20 years. Conventional chemotherapeutic regimens, which almost invariably include cytarabine and anthracyclines, are untargeted, and more specific therapies are needed.OBJECTIVE:
We have chosen acute myeloid leukemia as a disease prototype to review established and novel targeted approaches in leukemia treatment.METHODS:
Our selection of the reviewed literature focused on drug delivery aspects.CONCLUSION:
While the toxicity profile of chemotherapeutics has been improved by liposomal formulations and antibody conjugation for leukemia-directed uptake, their efficacy has probably not changed significantly. Drugs with an alternative mode of action, including kinase inhibitors, hold great promise. Further improvements may result from the characterization of novel acute myeloid leukemia (AML) cell surface receptors and of leukemic stem cells, as well as from the design of leukemia-targeted gene therapy vectors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article