Outbreak of necrotizing enterocolitis caused by norovirus in a neonatal intensive care unit.
J Pediatr
; 153(3): 339-44, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18534621
ABSTRACT
OBJECTIVES:
To investigate an outbreak of necrotizing enterocolitis (NEC) in a neonatal intensive care unit (NICU) and to identify the etiology, describe illness risk factors, and develop control measures. STUDYDESIGN:
A retrospective case-control study was performed including newborns with NEC and newborns without NEC, examining demographic factors and exposures to medications, staff members, and procedures before illness. Stool samples from affected newborns were collected and tested for bacteria, parasites, and viruses.RESULTS:
We confirmed a NEC outbreak in the NICU in January 1998 with 8 cases, including 2 deaths, clustered in time and space. Norovirus-like particles were identified in all available stools from cases; norovirus (NoV) was confirmed with reverse transcriptase polymerase chain reaction in 4 of 6 samples. NEC cases were younger, had lower Apgar scores, and received antibiotics longer than 25 control subjects. Three NICU health care personnel had more contact with cases than control subjects; 1 staff member recalled having gastroenteritis symptoms around the time of the outbreak.CONCLUSIONS:
This report associates NoV with NEC. NoV appeared to precipitate NEC in predisposed infants. Spatial clustering and epidemiologic links between cases and a health care worker with gastroenteritis suggests that NoV should be investigated among the etiologies of NEC outbreaks and that interventions targeted to interruption of NoV transmission should be considered.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA Viral
/
Unidades de Terapia Intensiva Neonatal
/
Infecção Hospitalar
/
Surtos de Doenças
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Transmissão de Doença Infecciosa do Profissional para o Paciente
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Enterocolite Necrosante
/
Norovirus
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Male
/
Newborn
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article