Staphylococcus aureus cell wall stress stimulon gene-lacZ fusion strains: potential for use in screening for cell wall-active antimicrobials.
Antimicrob Agents Chemother
; 52(8): 2923-5, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18541730
ABSTRACT
lacZ fusion strains were constructed using the promoters of five cell wall stress stimulon genes pbp2, tcaA, vraSR, sgtB, and lytR. All fusion strains were induced only in the presence of cell wall-active antibiotics, suggesting the potential of these strains for use in high-throughput screening for new cell wall-active agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Proteínas de Bactérias
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Parede Celular
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Óperon Lac
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Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article