[C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China].

ABSTRACT

OBJECTIVE: To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China. METHODS: Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism. RESULT: The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian. CONCLUSION: The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.