Neuroimaging of mirtazapine enantiomers in humans.
Psychopharmacology (Berl)
; 200(2): 273-9, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18566802
ABSTRACT
INTRODUCTION:
Mirtazapine is a racemic antidepressant with a multireceptor profile. Previous studies have shown that the enantiomers of mirtazapine have different pharmacologic effects in the brain of laboratory animals. MATERIALS ANDMETHODS:
In the present study, we used positron emission tomography (PET) and autoradiography to study effects of (R)- and (S)-[(11)C]mirtazapine in the human brain. Detailed brain imaging by PET using three methods of kinetic data analysis showed no reliable differences between regional binding potentials of (R)- and (S)-[(11)C]mirtazapine in healthy subjects.RESULTS:
Autoradiographic studies carried out in whole hemispheres of human brain tissue showed, however, that (R)- and (S)-mirtazapine differ markedly as inhibitors of [(3)H]clonidine binding at alpha(2)-adrenoceptors.CONCLUSION:
The multireceptor binding profiles of mirtazapine enantiomers, along with individual differences between subjects, may preclude PET neuroimaging from demonstrating reliable differences between the regional distribution and binding of (R)- and (S)-[(11)C]mirtazapine in the living human brain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Tomografia por Emissão de Pósitrons
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Mianserina
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Antidepressivos Tricíclicos
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article