Mushroom acidic glycosphingolipid induction of cytokine secretion from murine T cells and proliferation of NK1.1 alpha/beta TCR-double positive cells in vitro.
Biochem Biophys Res Commun
; 373(3): 435-9, 2008 Aug 29.
Article
em En
| MEDLINE
| ID: mdl-18577373
ABSTRACT
Interferon (IFN)-gamma and interleukin (IL)-4 regulate many types of immune responses. Here we report that acidic glycosphingolipids (AGLs) of Hypsizigus marmoreus and Pleurotus eryngii induced secretion of IFN- gamma and IL-4 from T cells in a CD11c-positive cell-dependent manner similar to that of alpha-galactosylceramide (alpha-GalCer) and isoglobotriaosylceramide (iGb3), although activated T cells by AGLs showed less secretion of cytokine than those activated by alpha-GalCer. In addition, stimulation of these mushroom AGLs induced proliferation of NK1.1 alpha/beta TCR-double positive cells in splenocytes. Administration of a mixture of alpha-GalCer and AGLs affected the stimulation of alpha-GalCer and generally induced a subtle Th1 bias for splenocytes but induced an extreme Th2 bias for thymocytes. These results suggested that edible mushroom AGLs contribute to immunomodulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Citocinas
/
Glicoesfingolipídeos Acídicos
/
Agaricales
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Fatores Imunológicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article