[Lung cancer diagnosis based on urinary modified nucleoside metabolic profiling].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 29(6): 738-41, 2007 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-18595249
ABSTRACT
OBJECTIVE:
To study the feasibility of modified urinary nucleosides metabolic profiling on lung cancer diagnoses.METHODS:
The modified urinary nucleosides metabolic profiling from 42 normal adults and 80 patients with lung cancer were determined by a coupled-column high performance liquid chromatography system. Partial least squares-discriminant analysis (PLS-DA) models were used to class differentiation between the lung cancer patients and controls and to discover potential biomarkers.RESULT:
The PLS-DA model results showed that there was a clear differentiation between normal adults and lung cancers patients, with the value of prediction (Q2) equals to 0.744.CONCLUSION:
Modified urinary nucleosides metabolic profiling method is useful for lung cancer diagnoses.
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Base de dados:
MEDLINE
Assunto principal:
Metaboloma
/
Neoplasias Pulmonares
/
Nucleosídeos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article