Occurrence of the JAK2 V617F mutation in the Budd-Chiari syndrome.
Blood Coagul Fibrinolysis
; 19(5): 459-62, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18600100
ABSTRACT
Myeloproliferative diseases represent a major risk factor for Budd-Chiari syndrome. In 32 patients with Budd-Chiari syndrome, the JAK2 V617F mutation was detected, in heterozygous state, in 11 individuals (34.4%; 95% confidence interval 18.6-53.2). Eight patients with (72.7%; 95% confidence interval 39.0-94.0) and six without (28.6%; 95% confidence interval 11.3-52.2) the JAK2 V617F mutation had a diagnosis of myeloproliferative diseases before or at the occurrence of the venous thrombotic event. In three patients carrying the JAK2 V617F mutation, a myeloproliferative disease was not detected. Determination of the JAK2 V617F mutation may be useful to recognize patients with Budd-Chiari syndrome with or at risk for the subsequent development of overt myeloproliferative diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mutação de Sentido Incorreto
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Janus Quinase 2
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Síndrome de Budd-Chiari
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Transtornos Mieloproliferativos
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article