Orthologs of macrophage migration inhibitory factor from parasitic nematodes.
Trends Parasitol
; 24(8): 355-63, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18603473
ABSTRACT
Chronic helminth infections are associated with modulation of host cellular immune responses, presumably to prolong parasite survival within the mammalian host. This phenomenon is attributed, at least in part, to the elaboration of parasite molecules, including orthologs of host cytokines and receptors, at the host-parasite interface. This review describes recent progress in the characterization of macrophage migration inhibitory factor (MIF) orthologs from parasitic nematodes. The roles of these molecules in parasite developmental biology and pathogenesis are discussed. Further knowledge of the species-specific activities and three-dimensional structures of human and parasitic nematode MIF molecules should make them ideal targets for drug- and/or vaccine-based strategies aimed at nematode disease control.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores Inibidores da Migração de Macrófagos
/
Nematoides
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Infecções por Nematoides
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article