Potential role of type I interferons in the treatment of pituitary adenomas.
Rev Endocr Metab Disord
; 10(2): 125-33, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-18604644
ABSTRACT
Cytokines, particularly those endowed with pro-inflammatory properties, are known to influence the release of anterior pituitary hormones by a direct and indirect action at the level of pituitary gland and hypothalamus. Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies underline the fact that type I IFNs are involved in the regulation of the immune-endocrine circuitry. Treatment with type I IFNs of patients affected by chronic viral hepatitis, multiple sclerosis and tumors influences the secretion of pituitary hormones. This article reviews the current knowledge about the effects of IFN-alpha and IFN-beta on hypothalamic-pituitary function and describes the potential role of type I IFNs in the treatment of pituitary adenomas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Interferon Tipo I
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article