Long-term effects of D-003, a mixture of high molecular weight acids from sugarcane wax, on bones of ovariectomized rats: a one year study.
Pharmazie
; 63(6): 486-8, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18604996
ABSTRACT
This study was done to determine the long-term effect of D-003 on bones of ovariectomized (ovx) rats distrib-uted in 4 groups a false-operated and three groups of ovx rats one treated with the vehicle and two with D-003 (5 and 250 mg/kg). D-003 significantly prevented, in a dose-dependent fashion, the trabecular bone volume (TBV), trabecular number (TbN) and trabecular thickness (TbTh) reduction induced in ovx rats and the increase of trabecular separation (TbSp) osteoclast number (OcN) and osteoclast surface (OcS/BS) increased in the positive controls versus the sham group. It is concluded that D-003 administered for 12 months prevented bone loss and decreased bone resorption in ovx rats, without evidences of impaired bone quality.
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Base de dados:
MEDLINE
Assunto principal:
Ceras
/
Saccharum
/
Conservadores da Densidade Óssea
/
Ácidos Graxos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article