Complexes of the copper-containing amine oxidase from Arthrobacter globiformis with the inhibitors benzylhydrazine and tranylcypromine.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 64(Pt 7): 577-83, 2008 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-18607080
ABSTRACT
Complexes of Arthrobacter globiformis amine oxidase (AGAO) with the inhibitors benzylhydrazine and tranylcypromine (an antidepressant drug) have been refined at 1.86 and 1.65 A resolution, respectively. Both inhibitors form covalent adducts with the TPQ cofactor. A tyrosine residue, proposed to act as a gate to the AGAO active site, is in its open conformation.
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Base de dados:
MEDLINE
Assunto principal:
Arthrobacter
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Proteínas de Bactérias
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Tranilcipromina
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Amina Oxidase (contendo Cobre)
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Inibidores Enzimáticos
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Hidrazinas
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article