The effects of intraperitoneal sildenafil administration on healing of left colonic anastomoses and intra-abdominal adhesion formation in the presence of intra-abdominal infection.
Dis Colon Rectum
; 51(12): 1837-41, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18607551
ABSTRACT
PURPOSE:
The objective of this pilot study was to establish an animal model for intra-abdominal infection and to examine the effect of sildenafil on anastomotic healing of the left colon and intra-abdominal adhesion formation.METHODS:
Fourteen Winstar rats underwent colonic transsection and primary anastomosis after performing intra-abdominal infection. Rats were divided into two groups Group 1 (n = 7) intra-abdominal infection, resection, and anastomoses; Group 2 (n = 7) intra-abdominal infection, resection, anastomoses, and sildenafil. Anastomotic bursting pressures, hydroxyproline levels, histopathologic grading, and abdominal adhesions were accessed on the postoperative Day 7.RESULTS:
Anastomotic healing was found to be improved in terms of a bursting pressure (P = 0.02). Histopathological examination revealed an increase in angiogenesis (P = 0.007). Moreover, intra-abdominal adhesions were significantly less in rats given sildenafil (P = 0.03).CONCLUSION:
Sildenafil may improve anastomotic healing of the left colon and diminishes peritoneal adhesion formation in the presense of abdominal infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peritonite
/
Inibidores de Fosfodiesterase
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Piperazinas
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Sulfonas
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Cicatrização
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Anastomose Cirúrgica
/
Colo
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article