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Microtesla MRI of the human brain combined with MEG.
Zotev, Vadim S; Matlashov, Andrei N; Volegov, Petr L; Savukov, Igor M; Espy, Michelle A; Mosher, John C; Gomez, John J; Kraus, Robert H.
Afiliação
  • Zotev VS; Los Alamos National Laboratory, Applied Modern Physics Group, MS D454, Los Alamos, NM 87545, USA. vzotev@lanl.gov
J Magn Reson ; 194(1): 115-20, 2008 Sep.
Article em En | MEDLINE | ID: mdl-18619876
ABSTRACT
One of the challenges in functional brain imaging is integration of complementary imaging modalities, such as magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). MEG, which uses highly sensitive superconducting quantum interference devices (SQUIDs) to directly measure magnetic fields of neuronal currents, cannot be combined with conventional high-field MRI in a single instrument. Indirect matching of MEG and MRI data leads to significant co-registration errors. A recently proposed imaging method--SQUID-based microtesla MRI--can be naturally combined with MEG in the same system to directly provide structural maps for MEG-localized sources. It enables easy and accurate integration of MEG and MRI/fMRI, because microtesla MR images can be precisely matched to structural images provided by high-field MRI and other techniques. Here we report the first images of the human brain by microtesla MRI, together with auditory MEG (functional) data, recorded using the same seven-channel SQUID system during the same imaging session. The images were acquired at 46 microT measurement field with pre-polarization at 30 mT. We also estimated transverse relaxation times for different tissues at microtesla fields. Our results demonstrate feasibility and potential of human brain imaging by microtesla MRI. They also show that two new types of imaging equipment--low-cost systems for anatomical MRI of the human brain at microtesla fields, and more advanced instruments for combined functional (MEG) and structural (microtesla MRI) brain imaging--are practical.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Interpretação de Imagem Assistida por Computador / Magnetoencefalografia / Técnica de Subtração Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética / Interpretação de Imagem Assistida por Computador / Magnetoencefalografia / Técnica de Subtração Tipo de estudo: Diagnostic_studies / Evaluation_studies Limite: Humans Idioma: En Ano de publicação: 2008 Tipo de documento: Article