The multiple facets of toll-like receptors in transplantation biology.
Transplantation
; 86(1): 1-9, 2008 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-18622268
ABSTRACT
Toll-like receptors (TLRs) belong to a family of pattern-recognition receptors for microbial products and endogenous molecules released by stressed cells. Experimental studies show that TLRs are involved in the process of acute allograft rejection and that their activation can prevent transplantation tolerance. Herein, we review the expression of TLRs and the impact of TLR signaling in different cell types in grafted organs including antigen-presenting cells, T and B lymphocytes, epithelial and endothelial cells. We then discuss the involvement of TLRs in the different phases of the rejection phenomenon and the impact of TLR-mediated events on regulatory circuits which dampen alloimmune responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunologia de Transplantes
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Traumatismo por Reperfusão
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Transdução de Sinais
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Tolerância ao Transplante
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Receptores Toll-Like
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article