Use of fluorescent in situ hybridization for marker chromosome identification in congenital and neoplastic disorders.
Am J Clin Pathol
; 96(2): 203-10, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1862775
ABSTRACT
Identifying marker chromosomes of unknown origin in the clinical cytogenetics laboratory has been a problem historically, despite advances in specialized staining techniques. Determination of the origin of these marker chromosomes in patients with congenital or malignant neoplastic disorders is essential for more complete diagnosis, counseling, and treatment. The authors describe the use of fluorescent in situ hybridization with chromosome-specific alpha-satellite DNA probes to identify the origin of marker chromosomes in two patients with congenital disorders and three patients with malignant neoplastic disorders. The impact of firm identification of the marker chromosome for the diagnosis of these patients is discussed. The authors also discuss the feasibility of using this technique routinely in the clinical cytogenetics laboratory.
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Base de dados:
MEDLINE
Assunto principal:
Anormalidades Congênitas
/
Mapeamento Cromossômico
/
Corantes Fluorescentes
/
Neoplasias
/
Hibridização de Ácido Nucleico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article