Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
Bioorg Med Chem Lett
; 18(15): 4298-302, 2008 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-18632269
ABSTRACT
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Estearoil-CoA Dessaturase
/
Ureia
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article