Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings.
J Cardiovasc Pharmacol Ther
; 13(3): 207-13, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18635753
ABSTRACT
Rosuvastatin was tested on rat aortic rings in the presence and absence of K(+) channel blockers, mevalonic acid, and inhibitors of nitric oxide, prostaglandins, or endothelial-derived hyperpolarizing factor synthesis. The direct vascular effects of rosuvastatin were then evaluated by obtaining dose-response curves. Rosuvastatin relaxed aortic rings with and, to a lesser degree, without endothelium. Under both these conditions this effect was partially inhibited by L-NAME, tetraethylammonium, apamin + charybdotoxin (only administered together), or mevalonic acid. The combination of L-NAME with any of the other 3 treatments completely inhibited the effect of rosuvastatin, but indomethacin, clotrimazol, glibenclamide, charybdotoxin, or apamin alone had no effect. Therefore, the relaxation induced by rosuvastatin, even in the absence of endothelium, is partially related to 2 different mechanisms, one that is isoprenoid dependent and NO mediated and the other that is tied to the opening of Ca( 2+)-dependent K(+) channels of the slow subfamily.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aorta Torácica
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Pirimidinas
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Sulfonamidas
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Vasodilatação
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Vasodilatadores
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Endotélio Vascular
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Canais de Potássio Cálcio-Ativados
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Fluorbenzenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article