Evaluation of a measles vaccine campaign in Ethiopia using oral-fluid antibody surveys.
Vaccine
; 26(37): 4769-74, 2008 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-18644417
ABSTRACT
We undertook a study to demonstrate the potential contribution of oral-fluid (OF) antibody prevalence surveys in evaluating measles vaccine campaigns. In Asela town, southern Ethiopia, oral fluids were collected from 1928 children aged 9 months to 5 years attending for campaign immunization in December 1999 and 6 months later, from 745 individuals aged 9 months to 19 years, in the same location. Measles antibody status was determined by microimmune measles specific IgG enzyme immunoassay (EIA). Antibody prevalence was estimated at 48% in children attending for vaccination (pre-campaign), and 85% post-campaign in the comparable age group. The estimated reduction in the susceptible proportion was 75%. In older children the proportion antibody negative post-campaign was 28% in 7-9 year olds, and 13% in 10-14 year olds levels of susceptibility which raise concern over continued measles transmission. This is the first evaluation of a measles vaccine campaign based on oral-fluid seroprevalence surveys and it demonstrates the merit of oral-fluid surveys in informing health authorities about vaccination strategy refinement.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacina contra Sarampo
/
Vacinação em Massa
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Sarampo
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Anticorpos Antivirais
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Mucosa Bucal
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Infant
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article