Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.
J Neuroimmunol
; 201-202: 41-9, 2008 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-18649950
ABSTRACT
CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Investigating the T cell response to the epsilon subunit of human AChR, we explore complementary in vitro and in vivo approaches (PBMC from MG patients and mice transgenic for HLA-DR3 and human CD4) to address the possibilities and limitations of different strategies for elucidating natural autoimmune T cell epitopes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores Nicotínicos
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Linfócitos T Auxiliares-Indutores
/
Mapeamento de Epitopos
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Miastenia Gravis
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Epitopos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article