Chiral NHC-catalyzed oxodiene Diels-Alder reactions with alpha-chloroaldehyde bisulfite salts.
Org Lett
; 10(17): 3817-20, 2008 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-18656948
ABSTRACT
Alpha-chloroaldehyde bisulfite adducts were successfully employed in chiral NHC-catalyzed hetero-Diels-Alder reactions with various oxodienes under biphasic reaction conditions with high levels of enantioselectivity. This new protocol makes possible enantioselective additions from commercially available chloroacetaldehyde sodium bisulfite and demonstrates that this unique class of catalysts readily tolerates aqueous conditions.
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Base de dados:
MEDLINE
Assunto principal:
Aldeídos
/
Compostos Heterocíclicos
/
Metano
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article