Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.
Ann Neurol
; 64(3): 348-52, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18661559
ABSTRACT
We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid pathology. The intron 4 marker rs2572324 was associated with the extent of neurofibrillary pathology (p = 0.0006, permuted p = 0.004; Braak stages IV-VI vs 0-II). The same variant also showed a trend for association with neocortical Lewy-related pathology. These results suggest for the first time that variation of alpha-synuclein modulates neurofibrillary tau pathology and support the recent observations of an interaction of alpha-synuclein and tau in neurodegeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Emaranhados Neurofibrilares
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Proteínas tau
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Doenças Neurodegenerativas
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Alfa-Sinucleína
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Neurônios
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article