Prolactin evokes lactational transmission of larvae in mice infected with Toxocara canis.
Parasitol Int
; 57(4): 495-8, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18664391
ABSTRACT
We investigated the trans-lactational maternal-neonatal transmission of Toxocara canis larvae in mice, with particular interest in the role of prolactin in their migration to the mammary gland. Two female mice were infected with 300 T. canis eggs soon after delivery of 27 offspring. After 1 week of breast-feeding, seven larvae were recovered from 4 of 13 offspring. After 2 weeks of lactation, 101 larvae were recovered from all the remaining offspring. Daily prolactin administration (5 microg) was performed 2 weeks before T. canis infection and continued until 2 weeks after infection in six non-pregnant female mice, which resulted in larval accumulation in the mammary gland. Furthermore, prolactin administration in female mice that had been infected with T. canis 4 weeks prior to prolactin treatment induced migration of larvae into the mammary gland. These findings suggest that prolactin is a promoting factor contributing to lactational transmission of T. canis larvae in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prolactina
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Lactação
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Toxocaríase
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Toxocara canis
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Transmissão Vertical de Doenças Infecciosas
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Glândulas Mamárias Animais
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article