Improved attenuation correction via appropriate selection of respiratory-correlated PET data.
Comput Methods Programs Biomed
; 92(1): 90-8, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18676054
ABSTRACT
PURPOSE:
We propose a respiratory-correlated PET data processing method (called "BH-CT-based") based on breath-hold CT acquisition to reduce the smearing effect and improve the attenuation correction. The resulting images are compared with the ungated PET images acquired using a standard, free-breathing clinical protocol.METHODS:
The BH-CT-based method consisted of a list-mode acquisition with simultaneous respiratory signal recording. An additional breath-hold CT acquisition was also performed in order to define a tissue position from which PET events can be selected. A phantom study featured a 0.5-ml sphere (filled with 18F-fluorodeoxyglucose ((18)F-FDG) solution) pushed onto a rubber balloon (filled with (18)F-FDG solution and iodinated contrast agent). The feasibility of the BH-CT-based method was also assessed in two patients.RESULTS:
In the phantom study, the contrast-to-noise ratios (CNRs) were -1.6 for the Ungated volume and 5.1 for the BH-CT-based volume. For patients, CNRs were higher for BH-CT-based volumes than those for Ungated volumes (17.3 vs. 6.3 and 7.3 vs. 3.8, for patients 1 and 2, respectively). Bias-variance measurements were performed and yielded bias reduction of 40% with BH-CT-based.CONCLUSION:
The application of a BH-CT-based method decreases motion bias in PET images. This method resolves issues related to both PET-to-CT misregistration and erroneous attenuation correction and increases lesion detectability.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interpretação de Imagem Assistida por Computador
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Aumento da Imagem
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Tomografia Computadorizada por Raios X
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Mecânica Respiratória
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Tomografia por Emissão de Pósitrons
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Técnicas de Imagem de Sincronização Respiratória
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Neoplasias
Tipo de estudo:
Diagnostic_studies
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Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article