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Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease.
Rigoli, Luciana; Romano, Claudio; Caruso, Rosario Alberto; Lo Presti, Maria A; Di Bella, Chiara; Procopio, Vincenzo; Lo Giudice, Giuseppina; Amorini, Maria; Costantino, Giuseppe; Sergi, Maria D; Cuppari, Caterina; Calabro, Giovanna Elisa; Gallizzi, Romina; Salpietro, Carmelo Damiano; Fries, Walter.
Afiliação
  • Rigoli L; Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico Universitario, Messina 98125, Italy. luciana.rigoli@unime.it
World J Gastroenterol ; 14(28): 4454-61, 2008 Jul 28.
Article em En | MEDLINE | ID: mdl-18680223
AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was significantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No significant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no significant association with G908R variant was found. L1007finsC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/CARD15, but not TLR4 SNPs, are associated with increased risk of CD.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Polimorfismo de Nucleotídeo Único / Receptor 4 Toll-Like / Proteína Adaptadora de Sinalização NOD2 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Polimorfismo de Nucleotídeo Único / Receptor 4 Toll-Like / Proteína Adaptadora de Sinalização NOD2 Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2008 Tipo de documento: Article