[The advances in research on phosphorylation of polyglutamine disease].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 25(4): 414-7, 2008 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-18683139
ABSTRACT
Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of a glutamine repeat in responsible gene products. To date, the pathogenesis of polyQ diseases is still not very clear, but many researches suggest that phosphorylation of mutant proteins plays a critical role on the process of Huntington's disease, dentatorubral-pallidoluysian atrophy, spinal bulbar muscular atrophy, spinocerebellar ataxia1 and spinocerebellar ataxia 3/Machado-Joseph disease.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Fosforilação
/
Expansão das Repetições de Trinucleotídeos
/
Transtornos Heredodegenerativos do Sistema Nervoso
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article