Ligand-based virtual screening to identify new T-type calcium channel blockers.
Channels (Austin)
; 1(4): 300-4, 2007.
Article
em En
| MEDLINE
| ID: mdl-18708747
ABSTRACT
T-type calcium channels are involved in the generation of rhythmical firing patterns in the mammalian central nervous system and in various pathological alterations of neuronal excitability such as in epilepsy or neuropathic pain. In the search for new T-type calcium channel blockers that would help to treat these disorders, we have followed a bi-dimensional pharmacophore-based virtual screening approach to identify new inhibitors. Nineteen molecules extracted from AurSCOPE Ion Channels knowledgebase were used as query molecules to screen an external database. This in silico approach was then validated using electrophysiology. Interestingly, 16 compounds out of 38 distinct molecules tested showed more than 50% blockade of the Ca(V)3.2 mediated T-type current. Two series of compounds show chemical originality compared with known T-type calcium channel blockers.
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Base de dados:
MEDLINE
Assunto principal:
Interface Usuário-Computador
/
Desenho de Fármacos
/
Desenho Assistido por Computador
/
Canais de Cálcio Tipo T
/
Neurônios
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2007
Tipo de documento:
Article