Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine.
J Infect Chemother
; 14(4): 333-6, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18709541
ABSTRACT
S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptococcus pneumoniae
/
Aderência Bacteriana
/
Carbocisteína
/
Células Epiteliais
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Expectorantes
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article