Synthesis and anti-CVB 3 evaluation of substituted 5-nitro-2-phenoxybenzonitriles.
Bioorg Med Chem Lett
; 18(18): 5123-5, 2008 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-18710805
ABSTRACT
The synthesis and SAR of a series of 60 substituted 2-phenoxy-5-nitrobenzonitriles (analogues of MDL-860) as inhibitors of enterovirus replication (in particular of coxsackievirus B3 (CVB 3)) are reported. Several of the analogues inhibited CVB 3 and other enteroviruses at low-micromolar concentrations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Enterovirus Humano B
/
Nitrilas
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article