Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits.
Nature
; 455(7214): 804-7, 2008 Oct 09.
Article
em En
| MEDLINE
| ID: mdl-18724361
Infection with antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a dangerous and costly complication of broad-spectrum antibiotic therapy. How antibiotic-mediated elimination of commensal bacteria promotes infection by antibiotic-resistant bacteria is a fertile area for speculation with few defined mechanisms. Here we demonstrate that antibiotic treatment of mice notably downregulates intestinal expression of RegIIIgamma (also known as Reg3g), a secreted C-type lectin that kills Gram-positive bacteria, including VRE. Downregulation of RegIIIgamma markedly decreases in vivo killing of VRE in the intestine of antibiotic-treated mice. Stimulation of intestinal Toll-like receptor 4 by oral administration of lipopolysaccharide re-induces RegIIIgamma, thereby boosting innate immune resistance of antibiotic-treated mice against VRE. Compromised mucosal innate immune defence, as induced by broad-spectrum antibiotic therapy, can be corrected by selectively stimulating mucosal epithelial Toll-like receptors, providing a potential therapeutic approach to reduce colonization and infection by antibiotic-resistant microbes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vancomicina
/
Enterococcus
/
Resistência a Vancomicina
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article