Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative.
Chem Commun (Camb)
; (34): 4034-6, 2008 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-18758617
ABSTRACT
The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophore petrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N1-(3,4-dihydroxbenzoyl)-spermidine, with N8-citryl-spermidine or N1-(3,4-dihydroxbenzoyl)-N8-citryl-spermidine, suggesting that N1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactin biosynthesis, contrary to previous suggestions.
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Base de dados:
MEDLINE
Assunto principal:
Bacillus anthracis
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Benzamidas
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Benzoatos
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Espermidina
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article