Novel oxidized derivatives of antifungal pyrrolnitrin from the bacterium Burkholderia cepacia K87.
J Antibiot (Tokyo)
; 61(7): 420-5, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18776654
ABSTRACT
The screening of antifungal active compounds from the fermentation extracts of soil-borne bacterium Burkholderia cepacia K87 afforded pyrrolnitrin (1) and two new pyrrolnitrin analogs, 3-chloro-4-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (2) and 4-chloro-3-(3-chloro-2-nitrophenyl)-5-methoxy-3-pyrrolin-2-one (3). Pyrrolnitrin showed strong antifungal activity against Rhizoctonia solani but the analogs (2 and 3) were found to be marginally active. The isolates, 2 and 3, are believed to be biodegraded derivatives of pyrrolnitrin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirrolnitrina
/
Burkholderia cepacia
/
Antifúngicos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article