Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
J Pediatr Endocrinol Metab
; 21(7): 665-72, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18780601
ABSTRACT
BACKGROUND:
The CTLA4 gene is involved in the activity of T cells.AIM:
To determine the association between Graves' disease (GD) susceptibility and CT60 polymorphism of the CTLA4 gene. PATIENTS 189 children with GD and 620 healthy controls.METHODS:
We determined the genotype with restriction fragment length polymorphism and compared results.RESULTS:
Genotype G/G was significantly associated with GD (odds ratio [OR] = 1.71, 95% confidence interval [CI] 1.20-2.44, Pc = 0.006); however, allele A could reverse its effect. Allele G was significantly more frequent (OR = 1.61, 95% CI 1.18-2.19, Pc = 0.0049) but allele A (OR = 0.62, 95% CI 0.46-0.85, Pc = 0.0049) and phenotype A (OR = 0.58, 95% CI 0.41-0.83, Pc = 0.006) were less frequent in patients with GD than in controls.CONCLUSION:
The CT60 SNP was associated with susceptibility to GD. The G allele increased the risk of GD.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Antígenos CD
/
Doença de Graves
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article