Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index.
J Intern Med
; 264(6): 586-92, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18783478
ABSTRACT
BACKGROUND AND OBJECTIVE:
High plasminogen activator inhibitor type 1 (PAI-1) activity is associated with inflammatory reactions and insulin resistance, but it is unclear what regulates PAI-1 activity at the low end. The purpose of this study was to investigate if patients with low PAI-1 activity have a lack of inflammatory response or a low insulin level.DESIGN:
Retrospective cohort study with internal controls.SUBJECTS:
Sixty-three patients referred for investigation of bleeding tendency and with low PAI-1 activity were compared with 118 patients with normal or high PAI-1 activity.OUTCOME:
Levels of C-peptide, proinsulin, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Adjustments were made for body mass index (BMI), oral oestrogens and age. Low PAI-1 activity was defined as less than 1 U mL(-1).RESULTS:
Body mass index in the low normal range, oral oestrogens, young age and low C-peptide were significantly associated with low PAI-1 activity and there was a trend for association with IL-6 in univariable analysis. The effect of age disappeared after correction for oral oestrogens and the effect of C-peptide and IL-6 disappeared after further adjustments. Low BMI remained as the strongest predictor of low PAI-1 activity.CONCLUSION:
Patients with bleeding tendency and low PAI-1 activity have inflammatory and insulin profiles similar to those with normal or high PAI-1, whereas BMI seems to be the most important determinant.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Massa Corporal
/
Inibidor 1 de Ativador de Plasminogênio
/
Hemorragia
/
Insulina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article