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Low-dose transdermal hormone therapy does not interfere with the blood pressure of hypertensive menopausal women: a pilot study.
de Carvalho, Márcia N; Nobre, Fernando; Mendes, Maria C; Dos Reis, Rosana M; Ferriani, Rui A; Silva de Sá, Marcos F.
Afiliação
  • de Carvalho MN; Sector of Endocrine Gynecology, Department of Gynecology and Obstetrics, University of São Paulo, São Paulo, Brazil. marcianevesc@oi.com.br
Blood Press Monit ; 13(5): 277-83, 2008 Oct.
Article em En | MEDLINE | ID: mdl-18799953
OBJECTIVES: To determine the effects of low-dose transdermal hormone therapy (HT) on systolic (SBP) and diastolic (DBP) blood pressure (BP) evaluated by 24-h ambulatory blood pressure monitoring (ABPM) in hypertensive postmenopausal women. METHODS: The study was conducted on 24 hypertensive postmenopausal women aged, on average, 54 years and under treatment with enalapril maleate (10-20 mg/day) combined or not with hydrochlorothiazide (25 mg/day). Thirteen women used a transdermal adhesive containing estradiol and norethisterone (25 and 125 mug active substance/day, respectively) and 11 did not receive HT. ABPM, lipid profile, and climacteric symptoms were evaluated before and 3 and 6 months after treatment. RESULTS: After 3 and 6 months of follow-up, there was a statistically significant reduction of the Blatt-Kupperman menopausal index in the treated group (19.6+/-8.3 vs. 9.6+/-5.9 vs. 9.7+/-7.0; P=0.01). No significant difference in any of the ABPM variables (areas under the systolic and diastolic curves, mean SBP and DBP, SBP and DBP loads and wakefulness-sleep variation) or in the lipid profile was observed between or within groups at the three time points studied. CONCLUSION: Low-dose transdermal HT administered for 6 months was effective in improving climacteric symptoms and did not change BP values or circadian pattern in postmenopausal women with mild-to-moderate arterial hypertension taking antihypertensive medications.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Reposição de Estrogênios / Estradiol / Hipertensão / Anti-Hipertensivos / Noretindrona Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia de Reposição de Estrogênios / Estradiol / Hipertensão / Anti-Hipertensivos / Noretindrona Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2008 Tipo de documento: Article