Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.
Bioorg Med Chem
; 16(19): 8818-23, 2008 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-18804380
ABSTRACT
Thiazolyl peptides are a class of thiazole-rich macrocyclic potent antibacterial agents. Recently, we described thiazomycin, a new member of thiazolyl peptides, discovered by a thiazolyl peptide specific chemical screening. This method also allowed for the discovery of a new thiazolyl peptide, thiazomycin A, which carries modification in the oxazolidine ring of the amino sugar moiety. Thiazomycin A is a specific inhibitor of protein synthesis (IC(50) 0.7 microg/mL) and a potent Gram-positive antibacterial agent with minimum inhibitory concentration (MIC) ranging 0.002-0.25 microg/mL. The isolation and structure elucidation and biological activities of thiazomycin A are described.
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1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
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Staphylococcus aureus
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Tiazóis
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Actinomycetales
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Antibacterianos
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article