The challenge of developing green tea polyphenols as therapeutic agents.
Inflammopharmacology
; 16(5): 248-52, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18815735
ABSTRACT
The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both in vitro and in vivo conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Chá
/
Catequina
Limite:
Humans
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article