Characterization of the papillomavirus alpha(1)E2 peptide unfolded to folded transition upon DNA binding.
FEBS Lett
; 582(25-26): 3619-24, 2008 Oct 29.
Article
em En
| MEDLINE
| ID: mdl-18834883
ABSTRACT
Transcriptional regulation depends on sequence-specific binding of regulatory proteins to their responsive elements in viral DNA. The papillomavirus E2 protein binds to DNA through the consensus sequence ACCG-NNNN-CGGT, activating or inhibiting viral replication. Through molecular dynamics simulations we were able to characterize the role of the DNA molecule on E2 binding region (named alpha(1)E2) conformation, acquiring structural insights for previous works suggesting an unfolded to folded transition upon alpha(1)E2 complexation to DNA. Moreover, the results indicate sites to guide the design of alpha(1)E2 synthetic derivatives to inhibit the HPV infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
DNA Viral
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Proteínas Oncogênicas Virais
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article