Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles.
Am J Physiol Heart Circ Physiol
; 295(6): H2280-8, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18835919
ABSTRACT
Impairment of flow-induced vasodilation in coronary resistance arterioles may contribute to the decline in coronary vasodilatory reserve that occurs with advancing age. This study investigated the effects of age on flow-induced signaling and activation of nitric oxide (NO)-mediated vasodilation in coronary resistance arterioles. Coronary arterioles were isolated from young (approximately 6 mo) and old (approximately 24 mo) male Fischer-344 rats to assess vasodilation to flow, vascular endothelial growth factor (VEGF), and ACh. Flow- and VEGF-induced vasodilation of coronary arterioles was impaired with age (P
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vasodilatação
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Envelhecimento
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Transdução de Sinais
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Circulação Coronária
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Vasos Coronários
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Receptor 2 de Fatores de Crescimento do Endotélio Vascular
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Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article