Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease.
Arch Neurol
; 65(10): 1348-52, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18852350
ABSTRACT
BACKGROUND:
A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed.OBJECTIVE:
To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD).DESIGN:
Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine.SETTING:
Referral center (PD and AD patients), primary care clinics, and community setting (controls).PARTICIPANTS:
Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n = 97) and control (n = 99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location. MAIN OUTCOMEMEASURES:
Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations.RESULTS:
Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = .02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = .03).CONCLUSIONS:
This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Vitamina D
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Deficiência de Vitamina D
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Doença de Alzheimer
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article