Biological activity of dilute isoproterenol solution stored for long periods in plastic bags.
Am J Hosp Pharm
; 34(7): 709-12, 1977 Jul.
Article
em En
| MEDLINE
| ID: mdl-18933
The effect of long-term storage in polyvinyl chloride bags on the biological activity and the chemical stability of isoproterenol was studied. A freshly prepared solution of isoproterenol, isoproterenol solution stored for six months and isoproterenol stored for 30 months were infused into the coronary circulation of 14 isolated rabbit hearts; heart rates were determined. Spectrophotometric studies to determine stability at various pH levels were also done. Aging of the solutions at pH 4 and at a concentration of 4 microgram/ml caused no significant impairment of their potency. Solutions above pH 6 were unstable.
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Base de dados:
MEDLINE
Assunto principal:
Cloreto de Polivinila
/
Polivinil
/
Embalagem de Medicamentos
/
Isoproterenol
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article