Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.
J Neurosci
; 28(43): 11003-14, 2008 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-18945908
ABSTRACT
Paranodal axoglial junctions are essential for the segregation of myelinated axons into distinct domains and efficient conduction of action potentials. Here, we show that netrin-1 and deleted in colorectal cancer (DCC) are enriched at the paranode in CNS myelin. We then address whether netrin-1 signaling influences paranodal adhesion between oligodendrocytes and axons. In the absence of netrin-1 or DCC function, oligodendroglial paranodes initially develop and mature normally but later become disorganized. Lack of DCC or netrin-1 resulted in detachment of paranodal loops from the axonal surface and the disappearance of transverse bands. Furthermore, the domain organization of myelin is compromised in the absence of netrin-1 signaling K+ channels inappropriately invade the paranodal region, and the normally restricted paranodal distribution of Caspr expands longitudinally along the axon. Our findings identify an essential role for netrin-1 and DCC regulating the maintenance of axoglial junctions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Oligodendroglia
/
Junções Comunicantes
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Receptores de Superfície Celular
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Proteínas Supressoras de Tumor
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Fatores de Crescimento Neural
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article