Carbon-fluorine bond formation.
Curr Opin Drug Discov Devel
; 11(6): 803-19, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18946845
ABSTRACT
A selection of carbon-fluorine bond-forming reactions that have been developed in the recent past are presented. An overview of the most common fluorination reagents is followed by descriptions of fluorination reactions that are organized by reactivity. The distinction between nucleophilic and electrophilic fluorinations is highlighted, as well as between aliphatic and aromatic fluorinations. Each section is divided into more specific reaction classes and examples for the synthesis of pharmaceuticals, [18F]radiolabeling and mechanistic investigations are provided.
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Base de dados:
MEDLINE
Assunto principal:
Carbono
/
Halogenação
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article