[RNase L, a crucial mediator of innate immunity and other cell functions]. / La RNase L, un acteur essentiel de la réponse cellulaire antivirale.
Med Sci (Paris)
; 24(10): 859-64, 2008 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-18950583
ABSTRACT
The 2-5A/RNase L pathway is one of the first cellular defences against viruses. RNase L is an unusual endoribonuclease which activity is strictly regulated by its binding to a small oligonucleotide, 2-5A. 2-5A itself is very unusual, consisting of a series of 5'- triphosphorylated oligoadenylates with 2'-5' bonds. But RNase L activity is not limited to viral RNA cleavage. RNase L plays a central role in innate immunity, apoptosis, cell growth and differentiation by regulating cellular RNA stability and expression. Default in its activity leads to increased susceptibility to virus infections and to tumor development. RNase L gene has been identified as HPC1 (Hereditary Prostate Cancer 1) gene. Study of RNase L variant R462Q in etiology of prostate cancer has led to the identification of the novel human retrovirus closely related to xenotropic murine leukemia viruses (MuLVs) and named XMRV.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nucleotídeos de Adenina
/
Endorribonucleases
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Imunidade Inata
Limite:
Animals
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Humans
/
Male
Idioma:
Fr
Ano de publicação:
2008
Tipo de documento:
Article