Human mitochondrial variants influence on oxygen consumption.
Mitochondrion
; 9(1): 27-30, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18952007
ABSTRACT
This work investigates if human mitochondrial variants influence on maximal oxygen consumption (VO(2max)). With this purpose we recruited, as a uniform population in term of nutritional habits and life style, 114 healthy male Spanish subjects that practiced fitness exercises 3-4 times a week. Once mtDNA haplogroups were determined, we found that J presents with lower VO(2max) (P=0.02) than nonJ variants. J has been related with a lower efficiency of electron transport chain (ETC), diminished ATP and ROS production. Thus, the difficult to compensate the mitochondrial energetic deficiency could explain the accumulation of J haplogroup in LHON and multiple sclerosis. Furthermore, the lower ROS production associated to J could also account for the accrual of this variant in elderly people consequent to a decreased oxidative damage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
/
Mitocôndrias
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article