[Clinical related factors of portal vein tumor thrombosis in patients with hepatocellular carcinoma: a logistic regression analysis].

ABSTRACT

OBJECTIVE: To investigate the related factors of portal vein tumor thrombosis (PVTT) in patients with HCC. METHODS: A total number of 234 patients with hepatocellular carcinoma (HCC) were included in this retrospective study. Uni-variate and multi-variate logistic regression analysis were employed to analyze the association between PVTT and 18 routine clinical parameters. RESULTS: Among the 234 patients with HCC, 15% of patients (35/235) had PVTT. Univariate logistic regression analysis revealed significant association of age (P = 0.016), gamma glutamyl transferase (GGT, P = 0.003), number of segmental invasion (P = 0.007), microvascular invasion (P < 0.01), segment location of S2 (P = 0.001), S3 (P = 0.000), S4 (P = 0.004) and S6 (P = 0.016). Multivariate analysis shows potential significant predictors of PVTT in HCC were age (RR 0.373; 95% CI 0.146-0.954; P = 0.040), the tumor location of S3 (RR 4.625; 95% CI 1.916-11. 165;P = 0.001), GGT (RR 4.091; 95% CI 1.448-11.553; P = 0.008) and microvascular invasion (RR 20.912; 95% CI 4.745-92.172; P < 0.01). CONCLUSIONS: PVTT occurred more commonly in the younger (< 50 years old), and those with high level of GGT, segment location of S3 and microvascular invasion.