The effect of iNOS inhibitors and hyperbaric oxygen treatment in a rat model of experimental colitis.
Dig Dis Sci
; 54(1): 75-9, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-18972208
ABSTRACT
AIM:
Our aim was to investigate the effectiveness of aminoguanidine (AMG), an inducible nitric oxide synthase inhibitor, and hyperbaric oxygen (HBO) treatment in an experimental colitis model.METHODS:
We induced colitis in rats. In the control group, we applied 2 ml serum physiologic intraperitoneally for 7 days. In the HBO group, 100% oxygen at 2.4 atm pressure was applied for 7 days. In the AMG group, 100 mg/kg AMG was applied intraperitoneally for 7 days. In the HBO + AMG group, HBO and AMG were applied, respectively. At the end of 7 days, rats were sacrificed and the distal 10 cm part of colon was examined macro- and microscopically.RESULTS:
Severity of colitis and NO activities were reduced by AMG, HBO, and HBO + AMG application. There was histologically significant improvement, especially in the HBO + AMG group.CONCLUSIONS:
Both HBO and AMG were significantly effective in preventing weight loss, reducing NO activities, and severity of colitis, when comparing HBO and AMG separately.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colite
/
Óxido Nítrico Sintase Tipo II
/
Guanidinas
/
Oxigenoterapia Hiperbárica
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article