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Bromocriptine use and the risk of valvular heart disease.
Tan, Louis C S; Ng, Kenneth K C; Au, Wing-Lok; Lee, Raymond K K; Chan, Yiong-Huak; Tan, Nigel C K.
Afiliação
  • Tan LC; Parkinson's Disease and Movement Disorders Centre, National Neuroscience Institute, Singapore. louis_tan@nni.com.sg
Mov Disord ; 24(3): 344-9, 2009 Feb 15.
Article em En | MEDLINE | ID: mdl-18989898
It has been reported that patients on pergolide and carbergoline have an increased risk of developing valvular heart disease. It is uncertain if bromocriptine, an ergot-derived dopamine agonist (DA) with partial 5-HT(2B) activity, is associated with a similar risk. We assessed the frequency of valvular heart disease in Parkinson's disease (PD) patients on bromocriptine compared to pergolide and a control group of PD patients who had not been treated on any DA. Seventy-two PD patients on bromocriptine, 21 patients on pergolide, and 47 control PD patients were recruited. Transthoracic echocardiographic studies were performed and reviewed by a blinded cardiologist. The risk for the bromocriptine group to develop any abnormal valvular regurgitation was 3.32 (adjusted OR, 95% CI: 1.11-9.92, P = 0.03) compared to controls, whereas the risk for the pergolide group was 3.66 (adjusted OR, 95% CI: 1.22-10.97, P = 0.02). When cumulative dose of bromocriptine was analyzed by quartiles, patients with a greater exposure to bromocriptine had significantly higher risk of developing both mild and moderate-severe regurgitations (P for trend, 0.005 and 0.019, respectively). This study demonstrated that bromocriptine use was associated with an increased risk of developing valvular heart disease, which occurred in a cumulative dose-dependent manner.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bromocriptina / Agonistas de Dopamina / Doenças das Valvas Cardíacas Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bromocriptina / Agonistas de Dopamina / Doenças das Valvas Cardíacas Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2009 Tipo de documento: Article